Sodium Hydroxide → 1152534-54-7

HRID 351242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351242
[OH-].[Na+].NC(NCCOC1C=CC([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[N:19]=[C:18]([C:29]([O:31]CC)=[O:30])[CH:17]=2)=CC=1)=O>C1COCC1.CO>[CH3:28][O:27][C:24]1[CH:23]=[CH:22][C:21]([N:20]2[CH:16]=[CH:17][C:18]([C:29]([OH:31])=[O:30])=[N:19]2)=[CH:26][CH:25]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 21091020HCID 21091020, Verbindung

Produkt 1

HCID 289740221152534-54-7Ausbeute 175,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1M NaOH (5 ml) was added to a solution of ethyl 5-(4-{2-[(aminocarbonyl)amino]ethoxy}phenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (1.75 g) in THF (15 ml) and MeOH (10 ml). The reaction mixture was stirred at ambient temperature and concentrated in vacuo. The residue was dissolved in H2O and acidified by 1M HCl. white precipitates were collected and washed successively with H2O and IPE to give 5-(4–12-[(aminocarbonyl)amino]-ethoxy}phenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid (1.58 g) as a white powder.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in H2O
  3. customwhite precipitates
  4. customwere collected
  5. washwashed successively with H2O and IPE

Quellen und Nachweise

ORD-Eintrag
ord-e9e3eccaf01242d29f5fdba52ad742b2
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183306B2

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