4-tert-Butylcyclohexylamine → N-(4-tert-Butylcyclohexyl)-N'-(7-hydroxynaphthalen-1-yl)urea

HRID 351286

Reaktionsgleichung

Reaktionsgleichung von HRID 351286
[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([NH2:11])[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].C1([O:18][C:19](=O)[NH:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=3)[CH:24]=[CH:23][CH:22]=2)C=CC=CC=1>CS(C)=O>[C:1]([CH:5]1[CH2:6][CH2:7][CH:8]([NH:11][C:19]([NH:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=3)[CH:24]=[CH:23][CH:22]=2)=[O:18])[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 793964-tert-ButylcyclohexylamineHCID 20090380(7-Hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester

Produkt 1

HCID 18435880N-(4-tert-Butylcyclohexyl)-N'-(7-hydroxynaphthalen-1-yl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

4-tert-Butyl-cyclohexylamine (69 mg, 0.44 mmol) and (7-hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester (125 mg, 0.44 mmol) were combined and stirred at ambient temperature in DMSO (3 mL) overnight. The product was purified by directly injecting the crude reaction onto a reverse phase prep-HPLC (90–10% water:acetonitrile gradient). The appropriate fractions were lyophilized to yield 1-(4-tert-Butyl-cyclohexyl)-3-(7-hydroxy-naphthalen-1-yl)-urea

Aufarbeitung

  1. customThe product was purified
  2. customreaction onto a reverse phase prep-HPLC (90–10% water:acetonitrile gradient)

Quellen und Nachweise

ORD-Eintrag
ord-75db14825a1f48a6961e36069b97b72c
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183411B2

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