Hydrochloric Acid → 2-Methylindol-4-yloxyacetic Acid

HRID 351643

Reaktionsgleichung

Reaktionsgleichung von HRID 351643
C[O:2][C:3](=[O:16])[CH:4]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2)[CH3:5].O1CCOCC1.[OH-].[Na+].Cl>CO>[CH3:5][CH:4]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2)[C:3]([OH:16])=[O:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 691303762-Methylindol-4-yloxyacetic Acid Methyl Ester

Produkt 1

HCID 695893972-Methylindol-4-yloxyacetic AcidAusbeute 69,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methylindol-4-yloxyacetic acid methyl ester (5.4 g) in methanol (18 ml)—dioxane (36 ml) was added 5N aqueous solution of sodium hydroxide (15 ml), and the mixture was stirred at room temperature for 1 hour. To the reaction solution was added 2N hydrochloric acid to give the title compound (3.5 g) having the following physical data.

Quellen und Nachweise

ORD-Eintrag
ord-e9bd21d5ed624234a0963aa400119c60
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06743793B2

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