Ethyl methanesulfonylacetate → Ethyl 3-dimethylamino-2-methylsulphonylacrylate

Reaktionsgleichung

[CH3:1][S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Komponenten

Edukt 2

HCID 78201Ethyl methanesulfonylacetate

HCID 78373Dimethylformamide dimethyl acetal

Produkt 1

HCID 57126670Ethyl 3-dimethylamino-2-methylsulphonylacrylate

Reaktionsbedingungen

Temperatur: 85 °C

Versuchsvorschrift

6.65 g (40 mmol) of ethyl methanesulphonylacetate and 5.72 g (48 mmol) of N,N-dimethylformamide dimethyl acetal are admixed and heated at 85° C. overnight. The solution is concentrated using a rotary evaporator, and the solid is comminuted with cyclohexane and filtered off with suction.

Aufarbeitung

concentrationThe solution is concentrated
customa rotary evaporator
customthe solid is comminuted with cyclohexane
filtrationfiltered off with suction

Quellen und Nachweise

ORD-Eintrag: ord-d5b98d3c965f4e9796d425aac5851886
Quelldatensatz: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06743798B1

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