Triphenylphosphine → 5-(S)-Aminomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]oxazolidine-2-one
Reaktionsgleichung
NC[C@@H]1OC(=O)N(C2C=CC(S(C)=O)=C(F)C=2)C1.[N:19]([CH2:22][C@H:23]1[O:27][C:26](=[O:28])[N:25]([C:29]2[CH:34]=[CH:33][C:32]([S:35]([CH2:37][CH2:38][F:39])=[O:36])=[C:31]([F:40])[CH:30]=2)[CH2:24]1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[NH2:19][CH2:22][C@@H:23]1[O:27][C:26](=[O:28])[N:25]([C:29]2[CH:34]=[CH:33][C:32]([S:35]([CH2:37][CH2:38][F:39])=[O:36])=[C:31]([F:40])[CH:30]=2)[CH2:24]1Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
This compound was prepared analogously to the synthesis of 5-(S)-aminomethyl-3-[4′-methylsulfinyl-3′-fluorophenyl]oxazolidine-2-one from 5-(S)-azidomethyl-3-[4′-(2″-fluoroethyl)sulfinyl-3′-fluorophenyl]oxazolidine-2-one (0.275 g, 0.833 mmol) and triphenylphosphine (0.229 g, 0.874 mmol). Yield 0.253 g (80%). MS (m/z): [M+H]+=305.