Triethylamine → HCID 22714422, Verbindung

HRID 351933Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351933
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.Br.CC1C([C:22]2[NH:23][CH2:24][CH2:25][N:26]=2)=C(C)NN=1.C(N(CC)CC)C>CN(C=O)C>[NH:26]1[CH2:25][CH2:24][N:23]=[C:22]1[NH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 22714433HCID 22714433, VerbindungHCID 534351342-(3,5-Dimethylpyrazolyl)-4,5-dihydroimidazole hydrobromide

Produkt 1

HCID 22714422HCID 22714422, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

500 mg (2.6 mmol) of 6-(3-aminopropoxy)indole 23 [prepared in accordance with Example 9.1] are dissolved in 10 ml of DMF together with 0.97 g (3.9 mmol) of 2-(3,5-dimethylpyrazolyl)-4,5-dihydroimidazole hydrobromide and 1.7 ml (11.9 mmol) of triethylamine, and the solution is stirred at 60° C. for 12 hours. After the solution has been evaporated, the crude product is purified by preparative HPLC.

Aufarbeitung

  1. customAfter the solution has been evaporated
  2. customthe crude product is purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-4e580d69350a4fb78f11816bd2b49ae8
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06743810B2

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