Methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride → 2-(3-Pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride

HRID 35195Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 35195
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([O:21]C)=[O:20])[CH:15]=3)[CH:10]=2)[CH:3]=1>Cl>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)[CH:3]=1

Komponenten

3

Edukt 1

HCID 21295725Methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride

Produkt 1

HCID 704078322-(3-Pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 205 mg of methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride in 15 ml of 6N hydrochloric acid was refluxed for 18 hours. The solution was cooled to room temperature and the precipitate filtered off, washed with cold 6N hydrochloric acid followed by acetone and air dried to give 2-(3-pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride, m.p. 265°-270° C.

Aufarbeitung

  1. filtrationthe precipitate filtered off
  2. washwashed with cold 6N hydrochloric acid
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c5f8d1cfcb224e08b8051b532a91ee86
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766127

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