Cesium carbonate → HCID 69663924, Verbindung

Beteiligte Stoffe

Reaktionsschritte

A mixture of palladium (II) acetate (500 mg), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (2.0 g) and cesium carbonate (10.3 g) in dry degassed 1,4-dioxane (120 ml) under argon was sonicated at 28° C. for 0.5 h producing a pink heterogeneous mixture. This was treated with D1 (6.0 g, 22 mmole) followed by cis-1,2,6-trimethylpiperazine (J. Med. Chem. 1968, 11, 592; 4.8 g, 38 mmole) and heated with rapid stirring at reflux for 70 h. The mixture was allowed to cool, filtered, then concentrated under vacuum. The residue was treated with water and extracted with EtOAc. The organic solution was then extracted with 1M HCl acid and the aqueous extract was basified by addition of K2CO3 and extracted with EtOAc. The extract was dried (Na2SO4) and concentrated under vacuum to leave an orange solid, which was chromatographed on silica gel eluting with 0-10% MeOH/DCM to afford the required product as a pale yellow solid (1.6 g, 23%).

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