Acetone → 259807-20-0

HRID 352736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 352736
[ClH:1].CC(C)=O.C(OC([N:13]1[CH2:18][CH2:17][N:16]([C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N+:28]=3[O-:33])=[CH:23][CH:22]=2)=[O:20])[CH2:15][CH2:14]1)=O)(C)(C)C>ClCCl.C(O)C>[ClH:1].[N:16]1([C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N+:28]=3[O-:33])=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]1

Komponenten

6

Edukt 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 69700183HCID 69700183, Verbindung

Produkt 1

HCID 22711429259807-20-0

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In dichloromethane (2.5 ml), 2-[4-[[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl]phenyl]pyridine N-oxide was dissolved. To the resulting solution, a saturated solution of hydrochloride in ethanol (2.5 ml) was added, followed by stirring at room temperature for 1 hour. After the solvent was distilled off under reduced pressure, water was added to the residue, whereby an aqueous solution was obtained. Acetone was added to the aqueous solution until the solution became turbid. The precipitate was collected by filtration and washed with acetone, whereby the title compound (274 mg, 81%) was obtained.

Aufarbeitung

  1. distillationAfter the solvent was distilled off under reduced pressure, water
  2. additionwas added to the residue, whereby an aqueous solution
  3. customwas obtained
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with acetone, whereby the title compound (274 mg, 81%)
  6. customwas obtained

Quellen und Nachweise

ORD-Eintrag
ord-53c7e3ae9c8842b384435d70f0881e39
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06747023B1

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