1-[(6-Chloronaphthalen-2-yl)sulfonyl]-3-methoxycarbonylmethylpiperazine → 4-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-methoxycarbonylmethyl-1-[4-(pyridin-2-yl)benzoyl]piperazine

HRID 352912Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 352912
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][NH:18][CH:17]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl.[N:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]1[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:37](=[O:38])[C:36]3[CH:40]=[CH:41][C:33]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][N:27]=4)=[CH:34][CH:35]=3)[CH:17]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[CH2:16]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2

Komponenten

3

Edukt 2

HCID 227094891-[(6-Chloronaphthalen-2-yl)sulfonyl]-3-methoxycarbonylmethylpiperazineHCID 684996434-(2-Pyridyl)benzoic acid hydrochloride

Produkt 1

HCID 186289224-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-methoxycarbonylmethyl-1-[4-(pyridin-2-yl)benzoyl]piperazine

Versuchsvorschrift

In the same manner as in Example A-68, a reaction was conducted using 1-[(6-chloronaphthalen-2-yl)sulfonyl]-3-methoxycarbonylmethylpiperazine (723 mg) and 4-(2-pyridyl)benzoic acid hydrochloride as starting materials, whereby the title compound was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-0b0af16959cd4ebc9d0336b873103d40
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06747023B1

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