Hydrochloric Acid → 4-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine-2-carbohydroxamic Acid

HRID 352960Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 352960
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH3:32])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH:17]([C:33](=[O:42])[NH:34][O:35]C3CCCCO3)[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH3:32])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH:17]([C:33]([NH:34][OH:35])=[O:42])[CH2:16]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 227106624-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-2-[[N-(tetrahydropyran-2-yloxy)]carbamoyl]piperazine

Produkt 1

HCID 227095664-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine-2-carbohydroxamic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In methanol (10 ml), 4-[(6-chloronaphthalen-2-yl)sulfonyl]-1-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-2-[[N-(tetrahydropyran-2-yloxy)]carbamoyl]piperazine (297 mg) was dissolved, followed by the addition of 1N hydrochloric acid (10 ml). The resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure. The residue was purified by “HP-20” (Φ1.7×20.0 cm, acetonitrile:water=1:5), whereby the title compound (65 mg) was obtained as a pale yellow foam.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by “HP-20” (Φ1.7×20.0 cm, acetonitrile:water=1:5), whereby the title compound (65 mg)
  3. customwas obtained as a pale yellow foam

Quellen und Nachweise

ORD-Eintrag
ord-f2345ad245b149768bf8fa021035a87d
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06747023B1

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