Ethanolamine → N-(2-Hydroxyethyl)pyrazine-2-carboxamide

HRID 35313

Reaktionsgleichung

Reaktionsgleichung von HRID 35313
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>C(OCC)(=O)C>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:9]

Komponenten

4

Edukt 2

HCID 700EthanolamineHCID 72662Methyl pyrazinoate

Produkt 1

HCID 14230272N-(2-Hydroxyethyl)pyrazine-2-carboxamideAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 55.2 parts of methyl 2-pyrazinecarboxylate, 48.9 parts of 2-aminoethanol and 360 parts of ethyl acetate was allowed to stand overnight at room temperature. The precipitated product was filtered off, washed with ethyl acetate and dried, yielding 54.5 parts (80%) of N-(2-hydroxyethyl)-2-pyrazinecarboxamide; mp. 125° C. (intermediate 22).

Aufarbeitung

  1. filtrationThe precipitated product was filtered off
  2. washwashed with ethyl acetate
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5c89f624e3c24f21936bf0d2ca764d41
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766125

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