Triethylamine → 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline

HRID 353130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 353130
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=1)=[O:23]>C(Cl)Cl>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH:11][C:22]([O:24][C:25]3[CH:26]=[CH:27][C:28]([N+:31]([O-:33])=[O:32])=[CH:29][CH:30]=3)=[O:23])=[CH:9][CH:8]=2)[CH2:5][CH2:6]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 821294-Nitrophenyl chloroformate

Produkt 1

HCID 227075274-morpholino-N-(4-nitrophenoxycarbonyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2.60 g (14.6 mmol) of 4-morpholinoaniline in 20 ml of methylene chloride were added 14.07 ml (105 mmol) of triethylamine and 3.53 g (17.5 mmol) of 4-nitrophenyl chloroformate under ice-cooling, followed by stirring at room temperature for 7 hours. After the solvent was evaporated, water was added to the residue, and the precipitated crystals were collected by filtration, washed water, and dried to give 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline.

Aufarbeitung

  1. temperaturecooling
  2. customAfter the solvent was evaporated
  3. additionwater was added to the residue
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3a7d66366e4f469389c1b27882ab0fdc
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06750218B2

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