Cadaverine → N-(5-Aminopentyl)benzamide

Reaktionsgleichung

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8](N)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

Edukt 2

HCID 273Cadaverine

HCID 2331Benzamide

Produkt 1

HCID 345353N-(5-Aminopentyl)benzamideAusbeute 70,6 %

Versuchsvorschrift

Under an argon atmosphere, 1,5-diaminopentane (25 g, 0.24 mol) and benzamide (9.9 g, 0.081 mol) were combined and heated at reflux overnight. The reaction mixture was concentrated under vacuum to remove the excess diamine. The residue was distilled at about 210° C. at 12 torr (16×102 pascals) to provide 11.8 g of N-(5-aminopentyl)benzamide as a colorless oil.

Aufarbeitung

temperatureheated
temperatureat reflux overnight
concentrationThe reaction mixture was concentrated under vacuum
customto remove the excess diamine
distillationThe residue was distilled at about 210° C. at 12 torr (16×102 pascals)

Quellen und Nachweise

ORD-Eintrag: ord-b381b192013040f686acf978ecc3b618
Quelldatensatz: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06756382B2

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