Sulfuric Acid → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

HRID 35385

Reaktionsgleichung

Reaktionsgleichung von HRID 35385
[Cl:1][CH2:2][O:3][C:4](F)(F)[CH:5]([C:10]([F:13])([F:12])[F:11])[C:6]([F:9])([F:8])[F:7].[Si](=O)=[O:17].S(=O)(=O)(O)O>>[F:7][C:6]([F:9])([F:8])[CH:5]([C:10]([F:13])([F:12])[F:11])[C:4]([O:3][CH2:2][Cl:1])=[O:17]

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 24261SilicaHCID 138276951-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane

Produkt 1

HCID 13954659Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoateAusbeute 92,8 %

Versuchsvorschrift

In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol) and silicon dioxide (50.8 g, 0.85 mol) were charged, and concentrated sulfuric acid (60 g, 0.61 mol) was dropwise added thereto while stirring. The reaction was continued at 110° C. for 21 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (192.9 g).

Aufarbeitung

  1. additionwere charged
  2. distillationThen, the reaction mixture was distilled

Quellen und Nachweise

ORD-Eintrag
ord-988e1b0b73ce447b954125e277789977
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766238

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