Hypofluorous acid, trifluoromethyl ester → Methanesulfonamide, N-phenyl-

HRID 35393

Reaktionsgleichung

Reaktionsgleichung von HRID 35393
FOC(F)(F)F.FOC(OF)(F)F.F[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH:21][S:22]([CH3:25])(=[O:24])=[O:23].FC1C=CC(NS(C)(=O)=O)=CC=1.FC1C=C(F)C=CC=1NS(C)(=O)=O.FC1C=CC=C(F)C=1NS(C)(=O)=O>>[C:16]1([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])[CH:15]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

7

Edukt 6

HCID 78989Hypofluorous acid, trifluoromethyl esterHCID 140054Bis(fluoroxy)perfluoromethaneHCID 669015N-(2-Fluorophenyl)methanesulfonamideHCID 669157N-(2,4-difluorophenyl)methanesulfonamideHCID 773417N-(4-fluorophenyl)methanesulfonamideHCID 13498497N-(2,6-difluorophenyl)methanesulfonamide

Produkt 1

HCID 70970Methanesulfonamide, N-phenyl-

Versuchsvorschrift

The procedure of Example 26 was repeated except that in place of the fluoroxytrifluoromethane, there was added bis-(fluoroxy)difluoromethane at a rate of 2.40 parts per hour for one hour. Analysis of the reaction product by liquid chromatographic techniques indicated 38% N-(2-fluorophenyl)methanesulfonamide, 12% N-(4-fluorophenyl)methanesulfonamide, 10% N-(2,4-difluorophenyl)methanesulfonamide and 1% N-(2,6-difluorophenyl)methanesulfonamide at 97% conversion.

Quellen und Nachweise

ORD-Eintrag
ord-760c8144346a4e968d0ba51e241675e6
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766243

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