3-Chloro-2-methylanisole → 3-Chloro-o-cresol

HRID 354261

Reaktionsgleichung

Reaktionsgleichung von HRID 354261
[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([O:8]C)[CH:5]=[CH:6][CH:7]=1>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 767493-Chloro-2-methylanisole

Produkt 1

HCID 148563-Chloro-o-cresol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

3.1 g (0.02 mol) of 3-chloro-2-methylanisole are heated in 20 ml of 50% sulphuric acid for 18 hours with reflux. After cooling, the reaction mixture is extracted three times with dichloromethane, dried over sodium sulphate and concentrated to dryness under reduced pressure. 3-Chloro-2-methylphenol is obtained as a solid (2.9 g, content by HPLC: 11.7%, 12% of theory).

Aufarbeitung

  1. temperaturewith reflux
  2. temperatureAfter cooling
  3. extractionthe reaction mixture is extracted three times with dichloromethane
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4f149bc2b5f84728ba42e39fa0b4c854
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06756512B2

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