Chloride → 17beta-Benzoyloxy-5alpha-androstan-4-one

HRID 354915Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 354915
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]2[C@H:17]3[C@H:27]([CH2:28][CH2:29][C@:12]12[CH3:13])[C@:25]1([CH3:26])[C@H:20]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24]1)[CH2:19][CH2:18]3.[Cl-]>N1C=CC=CC=1>[C:1]([O:10][C@H:11]1[CH2:16][CH2:15][C@H:14]2[C@H:17]3[C@H:27]([CH2:28][CH2:29][C@:12]12[CH3:13])[C@:25]1([CH3:26])[C@H:20]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24]1)[CH2:19][CH2:18]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 312ChlorideHCID 7412Benzoyl chlorideHCID 15341898HCID 15341898, Verbindung

Produkt 1

HCID 1534189917beta-Benzoyloxy-5alpha-androstan-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To 12 ml of dry pyridine and 6 ml of benzoyl chloride is added 2.0 g of the product of Step F to form a solution which is heated on a steam bath for 30 min. and then poured into 175 ml of ice water and stirred to decompose the excess chloride. The reaction mixture is filtered, washed with water, and pumped dry under high vacuum at 50° C. to yield 1.7 g of final product.

Aufarbeitung

  1. customto form a solution which
  2. temperatureis heated on a steam bath for 30 min.
  3. filtrationThe reaction mixture is filtered
  4. washwashed with water
  5. custompumped dry under high vacuum at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-20eaecd6abc74531a2c2484020935134
Quelldatensatz
uspto-grants-1983_03
Patentnummer
US04377584

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