Sodium hydride → 7-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-enanthic acid ethyl ester

HRID 355040

Reaktionsgleichung

Reaktionsgleichung von HRID 355040
[H-].[Na+].[C:3]1([N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[NH:11][C:10]2=[O:18])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:19]([O:21][C:22](=[O:30])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]Cl)[CH3:20]>CN(C=O)C>[CH2:19]([O:21][C:22](=[O:30])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][N:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N:9]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:10]1=[O:18])[CH3:20]

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 846572H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-HCID 529988Ethyl 7-chloroheptanoate

Produkt 1

HCID 543042887-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-enanthic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The product is produced as described in example 1 from 1.9 g. of NaH (80% suspension in mineral oil), 13.2 g. of 1-phenylbenzimidazolin-2-one (produced in usual manner by subjecting N-phenyl-o-phenylenediamine to reaction with phosgene), 120 cc. of DMF, 12.1 g. of 7-chloroenanthic acid ethyl ester and 1.9 g. of NaJ. Eluant in chromatographic purification: hexane/ethylacetate.

Aufarbeitung

  1. customThe product is produced
  2. customEluant in chromatographic purification

Quellen und Nachweise

ORD-Eintrag
ord-5de6ee76530c498fbd32795bab90ea10
Quelldatensatz
uspto-grants-1983_03
Patentnummer
US04377695

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