Methanol → 4-Benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide

HRID 355071

Reaktionsgleichung

Reaktionsgleichung von HRID 355071
[Br:1][CH:2]([CH3:12])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)=[O:4].[CH2:13]([C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CO>C(O)C>[Br-:1].[CH2:13]([C:20]1[CH:25]=[CH:24][N+:23]([CH:2]([C:3]([C:5]2[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=2)=[O:4])[CH3:12])=[CH:22][CH:21]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 164584-BenzylpyridineHCID 126131632-Bromo-1-(4-hydroxyphenyl)propan-1-one

Produkt 1

HCID 130521134-Benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In the condensation step, the condensation reaction between 2-bromo-4'-hydroxypropiophenone and 4-benzylpyridine is smoothly promoted in the presence of methanol and/or ethanol whereby a ketone compound of the general formula: ##STR2## i.e. 4-benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide is formed in the reaction mixture. The time and the temperature adopted for the condensation reaction are usually 3-6 hours and 60°-90° C., respectively. The reaction mixture thus obtained is directly subjected as such, without isolating the above condensation product, to the catalytic reduction in the subsequent step. In this case, an additional amount of methanol and/or ethanol may be supplied to the reaction mixture.

Aufarbeitung

  1. customIn the condensation step

Quellen und Nachweise

ORD-Eintrag
ord-22270f1a9cbb471da6a4bb893786a63d
Quelldatensatz
uspto-grants-1983_03
Patentnummer
US04377691

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