Benzoyl chloride → 2,5-anhydro-6-O-benzoyl-D-mannitol

7.9 g. (6.5 ml., 56.3 mmol.) of benzoyl chloride and 5.7 g. (8.02 ml., 56.3 mmol.) of triethylamine were added to a suspension of 8.4 g. (51.2 mmol.) of 2,5-anhydro-D-mannitol in 100 ml. of tetrahydrofuran. The reaction mixture was refluxed for 5 hrs., allowed to cool to room temperature and evaporated at room temperature and 200 ml. of chloroform is added to the residue. The solids were removed by filtration and washed with chloroform and the chloroform filtrate and washings were combined and evaporated at reduced pressure. The residue was filtered through 200 ml. of silica gel utilizing chloroform and 5% methanol/chloroform to elute the dibenzoate and 5% methanol/chloroform and 10% methanol/chloroform to elute the monobenzoate. The fractions containing the monobenzoate (as indicated by thin layer chromatography) were combined and evaporated at reduced pressure to an uncrystallizable, very thick oil. The oil was distilled in a Kugelrohr apparatus at 135°-145° C. and 40μ. to obtain a thick, pale yellow oil (2.50 g.) [α]D =+46.191° (methanol).

1. temperatureThe reaction mixture was refluxed for 5 hrs
2. customevaporated at room temperature
3. additionof chloroform is added to the residue
4. customThe solids were removed by filtration
5. washwashed with chloroform
6. customevaporated at reduced pressure
7. filtrationThe residue was filtered through 200 ml
8. washto elute the dibenzoate and 5% methanol/chloroform and 10% methanol/chloroform
9. washto elute the monobenzoate
10. additionThe fractions containing the monobenzoate (as indicated by thin layer chromatography)
11. customevaporated at reduced pressure to an uncrystallizable, very thick oil
12. distillationThe oil was distilled in a Kugelrohr apparatus at 135°-145° C.
13. customto obtain a thick, pale yellow oil (2.50 g.) [α]D =+46.191° (methanol)

ORD-Eintrag

ord-64df85ce323a4c5e8f74aa4659206277

Quelldatensatz

uspto-grants-1983_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04378369