HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Chloro-4-(trifluoromethyl)benzene → 4-(4-Trifluoromethylphenyl)morpholine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| Edukt | Morpholine | HCID 8083 | — |
| Edukt | Lithium Bromide | HCID 82050 | — |
| Edukt | Potassium tert-butoxide | HCID 23665647 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | — |
| Produkt | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | — |
Reaktionsschritte
2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of morpholine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium(II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenylmorpholine and 3-trifluoromethylphenylmorpholine in the ratio 5:1 in 62% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05831128 |
| Quelldatensatz | uspto-grants-1998_11 |
| ORD ID | ord-2218640268a64655b55ace309eaf0f6d |
| Quellennotiz | uspto-grants-1998_11 |