Nitric Acid → HCID 13037332, Verbindung

HRID 355823

Reaktionsgleichung

Reaktionsgleichung von HRID 355823
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].[N+:19]([O-])([OH:21])=[O:20]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([N+:19]([O-:21])=[O:20])=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 105078Ethyl Beta-Carboline-3-Carboxylate

Produkt 1

HCID 13037332HCID 13037332, VerbindungAusbeute 63 %

Versuchsvorschrift

9H-β-carboline-3-carboxylic acid ethyl ester (20 g, 833 mmol) was slowly added to concentrated nitric acid (400 mL). The reaction mixture was stirred at 70°-75° C. for 2 h. After cooling to room temperature the resulting mixture was poured onto ice (1 kg). The precipitated compound was collected, and recrystallized from pyridine (650 mL). This afforded the title compound (14.9 g, 63%). M.p. 339°-341° C.

Aufarbeitung

  1. additionwas poured onto ice (1 kg)
  2. customThe precipitated compound was collected
  3. customrecrystallized from pyridine (650 mL)

Quellen und Nachweise

ORD-Eintrag
ord-bde2ebc93c234b76abec48393aeae3d3
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05834482

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