Hydrochloric Acid → 3,5-Diamino-8-chloro-2,3-dihydro-quinoline-4-one

HRID 355967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 355967
Cl.C([N:5]1[C:14]2[C:9](=[C:10]([NH:16]C(=O)C)[CH:11]=[CH:12][C:13]=2[Cl:15])[C:8](=[O:20])[CH:7]([NH:21]C(=O)C)[CH2:6]1)(=O)C.[OH-].[Na+]>C(Cl)(Cl)Cl>[NH2:21][CH:7]1[C:8](=[O:20])[C:9]2[C:14](=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[NH2:16])[NH:5][CH2:6]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 224495101-Acetyl-3,5-diacetylamino-8-chloro-2,3-dihydro-quinoline-4-one

Produkt 1

HCID 224495153,5-Diamino-8-chloro-2,3-dihydro-quinoline-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

8 ml of 6N hydrochloric acid was added to 514 mg of the compound prepared in (2) above, and the mixture was heated at 110° C. for 1.5 hours while stirring. After cooling chloroform was added to it, followed by the addition of 50 ml of 1N aqueous solution of sodium hydroxide while stirring. The chloroform layer was extracted, the extract was washed with saturated brine and dried over anhydrous sodium sulfate. The product was concentrated to produce 260 mg of the title compound.

Aufarbeitung

  1. additionwas added to it
  2. stirringwhile stirring
  3. extractionThe chloroform layer was extracted
  4. washthe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationThe product was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-366694c31d8848099faec75b393412af
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05834476

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