Glycolic Acid → (5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

HRID 356328Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 356328
[NH2:1][C:2]1[C:3]([NH:11][CH3:12])=[N:4][C:5]([O:8][CH2:9][CH3:10])=[CH:6][CH:7]=1.[C:13]([OH:17])(=O)[CH2:14]O>>[CH2:9]([O:8][C:5]1[N:4]=[C:3]2[N:11]([CH3:12])[C:14]([CH2:13][OH:17])=[N:1][C:2]2=[CH:7][CH:6]=1)[CH3:10]

Komponenten

3

Edukt 2

HCID 757Glycolic AcidHCID 10583205HCID 10583205, Verbindung

Produkt 1

HCID 10560253(5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanolAusbeute 62,2 %

Versuchsvorschrift

A procedure similar to that described in Preparation 43 was repeated, except that 4.15 g 3-amino-6-ethoxy-2-methylaminopyridine (prepared as described in Preparation 97), and 5.66 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 3.20 g of the title compound, melting at 161° C.

Aufarbeitung

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and methanol as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-9ee7c56e009d4c0cb8ff320b2ad306b9
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05834501

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