Chlorotrimethylsilane → HCID 18630201, Verbindung

Reaktionsgleichung

[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>>[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:13]([CH3:15])([CH3:14])[CH3:12])[CH3:2]

Komponenten

Edukt 2

HCID 6397Chlorotrimethylsilane

HCID 11959N-Ethylbenzamide

Produkt 1

HCID 18630201HCID 18630201, VerbindungAusbeute 68,3 %

Versuchsvorschrift

N-Ethylbenzamide (74.5 g, 500 mmol) and TMSCl (135.8 g, 1.25 mol) were combined according to General Method C and purified by HPLC with 1:4 ethyl acetate/hexanes to afford 75.59 g of the title compound, as a white solid, a 68% yield. m.p. 64.0°-66.0° C.

Aufarbeitung

custompurified by HPLC with 1:4 ethyl acetate/hexanes

Quellen und Nachweise

ORD-Eintrag: ord-74b7af9748c941d2824e5477deb5adab
Quelldatensatz: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05834447

Notizen zur Reaktion

Wird geladen…