Propyl mercaptan → 1-(2-Bromo-1,1,2,2-tetrafluoroethoxy)-2-chloro-4-nitrobenzene

Temperatur

50 °C

Into a pressure bottle was placed 15.0 g (0.086 mole) 2-chloro-4-nitrophenol, 11.9 g (0.086 mole) potassium carbonate, 1.5 g (0.02 mole) propanethiol, 33.7 g (0.13 mole) 1,2-dibromotetrafluoroethane and 115 mL of N,N-dimethylformamide. The pressure bottle was sealed and the mixture stirred at 50° C. for 48 hours. The pressure bottle was cooled to room temperature, opened, and the contents poured into a separatory funnel. Approximately 200 mL of a 2N sodium hydroxide solution was added to the separatory funnel. The resultant mixture was extracted with four 300 mL portions of diethyl ether. The extracts were combined and washed with two 100 mL portions of a 2N sodium hydroxide solution. The washed extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure leaving an oil. The reaction described above was repeated three additional times. The residual oils from the four experiments were combined and purified by column chromatography on silica gel, eluting with n-heptane:toluene (95:5), to yield 57.6 g of 3-chloro4-(2-bromo-1,1,2,2-tetrafluoroethoxy)nitrobenzene as an oil.

1. customThe pressure bottle was sealed
2. temperatureThe pressure bottle was cooled to room temperature
3. additionthe contents poured into a separatory funnel
4. extractionThe resultant mixture was extracted with four 300 mL portions of diethyl ether
5. washwashed with two 100 mL portions of a 2N sodium hydroxide solution
6. extractionThe washed extract
7. dry with materialwas dried over anhydrous magnesium sulfate
8. filtrationfiltered
9. customThe filtrate was evaporated under reduced pressure
10. customleaving an oil
11. custompurified by column chromatography on silica gel
12. washeluting with n-heptane:toluene (95:5)

ORD-Eintrag

ord-fc02c6492469462ea497e11b404291a7

Quelldatensatz

uspto-grants-1988_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04767779