Hydrochloric Acid → HCID 178429829, Verbindung

HRID 357019

Reaktionsgleichung

Reaktionsgleichung von HRID 357019
Br.Cl[C:3]1[N:8]2[CH:9]=[C:10]([CH3:12])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.Cl.[SH-:14].[Na+]>>[SH:14][C:3]1[N:8]2[CH:9]=[C:10]([CH3:12])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 189367145-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

Produkt 1

HCID 178429829HCID 178429829, Verbindung

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

In a nitrogen atmosphere, 17.33 g (70 mmol) of 5-chloro-2-methylimidazo[1,2-a]pyridine hydrobromide was added to 70 ml of a sodium hydrosulfide solution at room temperature, followed by stirring at 90° C. for 24 hours. After the reaction mixture was cooled, concentrated hydrochloric acid was added until the reaction mixture's pH became 3-4. The resulting precipitate was collected by filtration, washed with water and dried to yield 12.32 g (quant, yellow powder) of the desired product.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-360c8d344a814fb89121864914482dc8
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05840732

Verknüpfte Notizen

Wird geladen…