Chloroacetaldehyde → 5-(4-Hydroxybutylthio)imidazo[1,2-c]pyrimidine

HRID 357024Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 357024
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[N:3]=1.Cl[CH2:15][CH:16]=O>C(O)C>[OH:13][CH2:12][CH2:11][CH2:10][CH2:9][S:8][C:4]1[N:3]2[CH:15]=[CH:16][N:1]=[C:2]2[CH:7]=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 33ChloroacetaldehydeHCID 189368114-Amino-2-(4-hydroxybutylthio)pyrimidine

Produkt 1

HCID 189368825-(4-Hydroxybutylthio)imidazo[1,2-c]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 4.98 g (25 mmol) of 4-amino-2-(4-hydroxybutylthio)pyrimidine in 70 ml of ethanol, 30 ml of a 40% chloroacetaldehyde solution was added, followed by refluxing for 4 hours. After the reaction mixture was cooled, the solvent was distilled off. The residue was dissolved in chloroform, washed with saturated aqueous sodium hydrogen carbonate and dried, after which the solvent was distilled off. The residue was purified by column chromatography (eluent, n-hexane/ethyl acetate=1/1→1/4→ethyl acetate) to yield 3.15 g (56.4%, white crystal) of the desired product.

Aufarbeitung

  1. temperatureby refluxing for 4 hours
  2. temperatureAfter the reaction mixture was cooled
  3. distillationthe solvent was distilled off
  4. dissolutionThe residue was dissolved in chloroform
  5. washwashed with saturated aqueous sodium hydrogen carbonate
  6. customdried
  7. distillationafter which the solvent was distilled off
  8. customThe residue was purified by column chromatography (eluent, n-hexane/ethyl acetate=1/1→1/4→ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-b32d3089c842437fb6246ce71bf7e620
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05840732

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