Hydrogen chloride-ethyl acetate → 5-Butylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride
Reaktionsgleichung
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[CH:23][N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:25])[CH2:2][CH2:3][CH3:4].[ClH:26].C(OCC)(=O)C>CO>[ClH:26].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([CH:22]=[CH:23][N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:25])[CH2:2][CH2:3][CH3:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a methanol solution of 0.17 g (0.59 mmol) of 5-butylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione, 0.13 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring, after which the solvent was distilled off, to yield 0.19 g (84.8%, yellow oily substance) of the desired product.