Methyl 3-bromothiophene-2-carboxylate → 3-Bromothiophene-2-carboxylic acid

HRID 357739

Reaktionsgleichung

Reaktionsgleichung von HRID 357739
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[Br:10])=[O:4]>CO.O1CCCC1.[OH-].[Na+]>[Br:10][C:9]1[CH:8]=[CH:7][S:6][C:5]=1[C:3]([OH:4])=[O:2]

Komponenten

5

Edukt 1

HCID 2740074Methyl 3-bromothiophene-2-carboxylate

Produkt 1

HCID 27396883-Bromothiophene-2-carboxylic acidAusbeute 97,3 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

3-Bromo-2-thiophenecarboxylic acid methyl ester (7.74 g) was dissolved in a mixture of methanol (35 ml) and tetrahydrofuran (35 ml), and 1N aqueous sodium hydroxide (53 ml) was added. The mixture was stirred at room temperature for 2 hours and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 3-bromo-2-thiophenecarboxylic acid (7.05 g) as crystals.

Aufarbeitung

  1. additionwas added
  2. washwashed with diethyl ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2e768a02cf3442ff911f2d68e5377a5c
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05840917

Verknüpfte Notizen

Wird geladen…