HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chloral → (2R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chloral | HCID 6407 | — |
| Edukt | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | (3R)-2-methyl-3-hydroxybutanoic acid | HCID 18633016 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | (2R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one | HCID 57161429 | 83,5% |
Reaktionsschritte
A mixture of (3R)-2-methyl-3-hydroxybutanoic acid 3.6 g, chloral 8.3 g, pyridinium p-toluenesulfonate (PPTS) 0.7 g and dichloromethane 20 ml was refluxed for 25 hours under a dehydration condition. 40 ml of a saturated aqueous sodium hydrogen carbonate was added thereto and the resulting separated organic phase was dried over anhydrous magnesium sulfate and the solvent was distilled off to obtain 6.3 g of (2R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05411877 |
| Quelldatensatz | uspto-grants-1995_05 |
| ORD ID | ord-1b232995cdb4485884eb9ac2fd24a0fa |
| Quellennotiz | uspto-grants-1995_05 |