Reaktionsgleichung
[CH2:1]([CH:4]([CH:12]([OH:14])[CH3:13])[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])[CH:2]=[CH2:3].C(OC=C)(=O)CCCCCCCCCCC>>[CH2:1]([CH:4]([C@@H:12]([OH:14])[CH3:13])[C:5]([O:7][C:8]([CH3:10])([CH3:9])[CH3:11])=[O:6])[CH:2]=[CH2:3]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 35 °C
Versuchsvorschrift
A mixture of 15.0 g of t-butyl 2-allyl-3-hydroxybutanoate as racemate, 13.7 g of vinyl laurate, and 8.0 g of Lipase P (trade name, supplied by Amano Pharmaceutical Co., Ltd.) was stirred at 35° C. for 9 days. After stopping the reaction, the enzyme was removed by filtration and the enzyme was washed with n-heptane on a filter paper. The filtrate was distilled away and the residue was subjected to vacuum distillation to give 6.8 g of t-butyl (3S)-2-allyl-3-hydroxybutanoate of the following formula, b.p. 79°-85° C. (5.0 mm Hg), [α]D30 =+5.0° (C=1.35, CHCl3). ##STR79## The NMR chart is shown in FIG. 9.
Aufarbeitung
- customthe reaction
- customthe enzyme was removed by filtration
- washthe enzyme was washed with n-heptane on a filter paper
- distillationThe filtrate was distilled away
- distillationthe residue was subjected to vacuum distillation
Quellen und Nachweise
- ORD-Eintrag
- ord-11639c4f87d5420bb254cba375d573f9
- Quelldatensatz
- uspto-grants-1995_05
- Patentnummer
- US05411877
Verknüpfte Notizen
Wird geladen…