Sodium hydride → 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline

Beteiligte Stoffe

Reaktionsschritte

To a mixture of 0.6 g of sodium hydride (50%, suspension in oil) and 2 g of 4-chloro-8-fluoroquinazoline in 20 ml of DMF was added 1.64 g of 2-(4-methylphenyl)ethanol, and the mixture was stirred for one hour. Then the mixture was poured into ice water. The solid was collected by filtration. Yield: 0.7 g (20.5%). M.P. 72°-74° C.

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