Piperidine → 6-Fluoro-3-hydroxy-1-methyl-4-quinolone

HRID 358680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 358680
C([O:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[N:12]([CH3:22])[CH:11]=1)(=O)C1C=CC=CC=1.N1CCCCC1>ClCCl>[F:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:22])[CH:11]=[C:10]([OH:9])[C:19]2=[O:20]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 542187166-Fluoro-1-methyl-4-oxo-1,4-dihydroquinol-3-yl benzoate

Produkt 1

HCID 231280776-Fluoro-3-hydroxy-1-methyl-4-quinolone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 6-fluoro-1 -methyl-4-oxo-1 ,4-dihydro-quinol-3-yl benzoate (1.90 g), piperidine (0.9 ml) and dry dichloromethane (50 ml) was stirred under nitrogen for 24 hours at ambient temperature. The solvent was removed by distillation and the residue triturated with diethyl ether (100 ml). The resultant solid was collected by filtration to give the novel compound 6-fluoro-3-hydroxy-1-methyl-4-quinolone, m.pp. 104°-106°.

Aufarbeitung

  1. customThe solvent was removed by distillation
  2. customthe residue triturated with diethyl ether (100 ml)
  3. filtrationThe resultant solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-21bd8084f693488d94d2a08d4c529084
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US04997840

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