Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride

HRID 358877

Reaktionsgleichung

Reaktionsgleichung von HRID 358877
[CH3:1][O:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7].S(Cl)([Cl:17])=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:17])=[O:7]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 27339702,4,5-Trifluoro-3-methoxybenzoic acid

Produkt 1

HCID 27752812,4,5-Trifluoro-3-methoxybenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a solution of 1.14 g (0.0055 mole) of 3-methoxy-2,4,5-trifluorobenzoic acid (XXVI) (prepared as described in Preparation 1 or 2) in 10 ml of dry benzene was added 5 ml of thionyl chloride and the mixture was heated under reflux for 1 hour. At the end of this time, benzene and the excess of thionyl chloride were removed completely to give 3-methoxy-2,4,5-trifluorobenzoyl chloride (XXVII) [Step (E7)].

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. customAt the end of this time, benzene and the excess of thionyl chloride were removed completely

Quellen und Nachweise

ORD-Eintrag
ord-e8340abe867a4d70b81c6228fb698fd8
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US04997943

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