HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethanol → 2,2-Dimethylcyclopentanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethanol | HCID 702 | — |
| Edukt | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Edukt | Hydroxyamine hydrochloride | HCID 443297 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Produkt | 2,2-Dimethylcyclopentanone | HCID 138286 | — |
| Produkt | 6,6-Dimethylpiperidin-2-one | HCID 1714407 | — |
Reaktionsschritte
The oxime of 2,2 dimethylcyclopentanone is prepared by reaction of the ketone with hydroxylamine hydrochloride in EtOH, and treated with p-toluenesulfonyl chloride and DMAP. Heating then effects Beckmann rearrangement to give 6,6-dimethyl-2-piperidinone which is deprotonated with NaH in DMF solution. Reaction with n-butyl iodide then gives the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05001113 |
| Quelldatensatz | uspto-grants-1991_03 |
| ORD ID | ord-a010d9c3c9ea409e9b454f9466a6ce01 |
| Quellennotiz | uspto-grants-1991_03 |