Tridecane → 3,4-Difluorobenzoic acid

HRID 359964

Reaktionsgleichung

Reaktionsgleichung von HRID 359964
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[O:8]C(=O)[C:5]2=[CH:11][C:12]=1[F:13].CCCCCCCCCCCCC>CN1CCCC1=O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:11][C:12]=1[F:13])[C:9]([OH:10])=[O:8]

Komponenten

4

Edukt 2

HCID 12388TridecaneHCID 6397454,5-Difluorophthalic Anhydride

Produkt 1

HCID 991663,4-Difluorobenzoic acidAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
190 °C

Versuchsvorschrift

4,5-difluorophthalic anhydride (0.5 grams, 2.7 mmole) was added to a slurry of cupric oxide (5% by weight of starting material) in 5 ml. of N-methyl-2-pyrrolidone. n-tridecane (0.25 grams) was added as an internal standard. The mixture was heated to 190° C. for 3 hours, at which time GC analysis indicated complete consumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 85% yield, based upon the internal standard, corrected for response factors.

Aufarbeitung

  1. customconsumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 85% yield

Quellen und Nachweise

ORD-Eintrag
ord-622f7889c5fd4a34bcfd850228f6c47e
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US05003103

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