Tridecane → 3,4-Difluorobenzoic acid

HRID 359965

Reaktionsgleichung

Reaktionsgleichung von HRID 359965
[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5](=[CH:9][C:10]=1[F:11])C(O)=O.CCCCCCCCCCCCC>CN1CCCC1=O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:9][C:10]=1[F:11])[C:12]([OH:14])=[O:13]

Komponenten

4

Edukt 2

HCID 12388TridecaneHCID 6433824,5-Difluorophthalic Acid

Produkt 1

HCID 991663,4-Difluorobenzoic acidAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
190 °C

Versuchsvorschrift

4,5-difluorophthalic acid (0.55 grams, 2.7 mmole) was added to a slurry of cupric oxide (10% by weight of starting material) in 5 ml. of N-methyl-2-pyrrolidone solvent. n-tridecane (0.25 grams) was added as an internal standard. The mixture was heated to 190° C. for 3 hours, at which time GC analysis indicated complete consumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield, based upon the internal standard, corrected for response factors.

Aufarbeitung

  1. customconsumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield

Quellen und Nachweise

ORD-Eintrag
ord-fcfd1f5b2bce4b5b97698e30056690df
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US05003103

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