Terazosin Hydrochloride → 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate

HRID 35999

Reaktionsgleichung

Reaktionsgleichung von HRID 35999
O.O.[ClH:3].[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[C:7]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][O:28]3)=[O:26])[CH2:21][CH2:20]2)[N:6]=1>CO>[CH3:12][O-:15].[ClH:3].[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[C:7]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][O:28]3)=[O:26])[CH2:21][CH2:20]2)[N:6]=1

Komponenten

3

Edukt 1

HCID 63016Terazosin Hydrochloride

Produkt 1

HCID 867486641-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolateAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride dihydrate (7.37. g, 16.0 mmol, prepared in accordance with the teachings of U.S. Pat. No. 4,25 1,532) was placed in an Edenmeyer flask and dissolved in a minimum amount (about 10 mL) of hot dry methanol. The solid initially dissolved, but soon turned cloudy and a precipitate formed. The precipitate was collected by filtration and washed with a small quantity of dry methanol followed by dry acetone to yield 6.35 g (13.9 mmol, 87.0%) of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate.

Aufarbeitung

  1. customg, 16.0 mmol, prepared in accordance with the teachings of U.S
  2. dissolutionThe solid initially dissolved
  3. customa precipitate formed
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with a small quantity of dry methanol

Quellen und Nachweise

ORD-Eintrag
ord-0d1412ab4e3b409890ef460da4092292
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05412095

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