Phosphorus tribromide → 6-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine

HRID 361408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 361408
[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[N:11]=[C:10]([CH2:12]O)[CH:9]=[CH:8][C:6]=2[N:7]=1.P(Br)(Br)[Br:16]>C1COCC1>[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[N:11]=[C:10]([CH2:12][Br:16])[CH:9]=[CH:8][C:6]=2[N:7]=1

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 13345225(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methanol

Produkt 1

HCID 133452266-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A suspension of 0.72 g (3.77 mmol) of 6 in 12 mL dry THF was stirred for 8 hours with 1 mL of phosphorus tribromide. The precipitated solid was filtered, washed with cold 50% THF-Ether, and dried to give 7. Because of the instability, this compound was not purified further. The 1HNMR showed that the majority of the solid was the desired compound.

Aufarbeitung

  1. filtrationThe precipitated solid was filtered
  2. washwashed with cold 50% THF-Ether
  3. customdried
  4. customto give 7
  5. customBecause of the instability, this compound was not purified further

Quellen und Nachweise

ORD-Eintrag
ord-e093bf24f1634bac8f07d61b20fb14a8
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866580

Notizen zur Reaktion

Wird geladen…