Ethyl 2-(piperidin-4-yl)acetate → N-4-cyanobenzoyl-beta-phenyl-alpha,alpha-dimethyl-beta-alanyl-4-piperidineacetic acid ethyl ester

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The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (1.0 g, 3.10 mmol) using ethyl 4-piperidine acetate (1.59 g, 9.31 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanyl-4-piperidineacetic acid ethyl ester (0.96 g, 65.1%).

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