3,5-Dichloro-4-(1-methylethylamino)pyridazine → 1-Benzyl-4-[N-methyl-N-(4-isopropylamino-5-chloro-3-pyridazinyl)amino]piperazine

HRID 361833Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 361833
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([NH:14][CH3:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16]([NH:19][C:20]1[C:25]([Cl:26])=[CH:24][N:23]=[N:22][C:21]=1Cl)([CH3:18])[CH3:17]>>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([N:14]([CH3:15])[C:21]2[N:22]=[N:23][CH:24]=[C:25]([Cl:26])[C:20]=2[NH:19][CH:16]([CH3:18])[CH3:17])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 108221363,5-Dichloro-4-(1-methylethylamino)pyridazineHCID 53908473HCID 53908473, Verbindung

Produkt 1

HCID 867536581-Benzyl-4-[N-methyl-N-(4-isopropylamino-5-chloro-3-pyridazinyl)amino]piperazine

Versuchsvorschrift

1-Benzyl-4-methylaminopiperazine (EXAMPLE 9, 2.30 g, 11.4 mmol) and 4-isopropylamino-3,5-dichloropyridazine (EXAMPLE 157, 1.0 g, 4.8 mmol) are heated in a sealed tube under a nitrogen atmosphere to 155° for 3 hr. The mixture is then chromatographed (silica gel, 150 g; 50-100% ethyl acetate/hexane) to give the title compound, NMR (300 MHz, CD3OD) 8.43, 7.30, 4.5, 3.51, 2.90, 2.72, 2.05, 1.75 and 1.21δ.

Aufarbeitung

  1. customThe mixture is then chromatographed (silica gel, 150 g; 50-100% ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-8ababa443c004cd9b96c4cbc9dfd34e6
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866589

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