1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine → 4-[N-Ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

HRID 361855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 361855
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:26][CH3:27])[C:15]2[C:20]([NH:21][CH:22]([CH3:24])[CH3:23])=[CH:19][CH:18]=[C:17]([F:25])[N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[CH2:26]([N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([NH:21][CH:22]([CH3:24])[CH3:23])=[CH:19][CH:18]=[C:17]([F:25])[N:16]=1)[CH3:27]

Komponenten

4

Edukt 1

HCID 105712191-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

Produkt 1

HCID 675760484-[N-Ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine (EXAMPLE 196, 2.1 g, 5.76 mmol) is dissolved in ethanol (100 ml) and 0.96 g of palladium hydroxide is added. The reaction is placed on a Parr hydrogenator at 40 psi for 12 hr. Then the reaction is filtered through diatomaceous earth, concentrated under reduced pressure, and used without further purification, NMR (300 MHz, CDCl3) 6.93, 6.55, 4.32, 3.51, 3.11, 3.10-2.95, 2.59, 1.77, 1.55, 1.18 and 0.86δ.

Aufarbeitung

  1. filtrationThen the reaction is filtered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure
  3. customused without further purification, NMR (300 MHz, CDCl3) 6.93, 6.55, 4.32, 3.51, 3.11, 3.10-2.95, 2.59, 1.77, 1.55, 1.18 and 0

Quellen und Nachweise

ORD-Eintrag
ord-afba2fbf3f1c412ea197430bde958041
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866589

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