1-Benzyl-4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine → 4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine

HRID 361858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 361858
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:24][CH3:25])[C:15]2[C:20]([NH:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[CH2:24]([N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:15]1[C:20]([NH:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1)[CH3:25]

Komponenten

4

Edukt 1

HCID 104972481-Benzyl-4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine

Produkt 1

HCID 107292464-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1-Benzyl-4-[N-ethyl-N-(3-(ethylamino)-2-pyridinyl)amino]piperidine (EXAMPLE 205, 0.41 g, 1.2 mmol) is dissolved in 20 ml of ethanol and 0.20 g of palladium hydroxide is added. The reaction is placed on a Parr hydrogenator under 40 psi for 24 hrs. Then it is filtered through diatomaceous earth and concentrated under reduced pressure to give the title compound, NMR (300 MHz, CDCl3) 7.60, 6.80, 6.67, 4.53, 3.76, 3.76, 3.15-2.95, 2.56, 1.76, 1.54, 1.12 and 0.73δ.

Aufarbeitung

  1. filtrationThen it is filtered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d9835ac6a15f487ab3745696857ef37e
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866589

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