Lithium azide → [2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl azide

HRID 36187

Reaktionsgleichung

Reaktionsgleichung von HRID 36187
[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21]Br)=[CH:17][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[N-:23]=[N+:24]=[N-:25].[Li+]>>[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:23]=[N+:24]=[N-:25])=[CH:17][CH:16]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 88163Lithium azideHCID 15282100[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide

Produkt 1

HCID 10427616[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl azideAusbeute 74 %

Versuchsvorschrift

Reaction of [2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl bromide (from Step D) with lithium azide was carried out according to the procedure of Example 9, Step A. The crude product was purified by flash chromatography on silica gel (elution with 10% EtOAc in hexane) to give a 74% yield of the title compound as a white solid; satisfactory purity (by TLC in 9:1 hexane-EtOAc) for use in the next step.

Aufarbeitung

  1. customThe crude product was purified by flash chromatography on silica gel (elution with 10% EtOAc in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-5b582a3dfc904b129bd9856a7382c53f
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05411980

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