5-n-Butyl-2,4-dihydro-2-(phenylthiomethyl)-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one → HCID 178441957, Verbindung

Beteiligte Stoffe

Reaktionsschritte

Deprotection of 5-n-butyl-2,4-dihydro-2-(phenylthiomethyl)-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one in 50% aqueous acetic acid was accomplished by the procedure of Example 3, Step B. After work-up, the residue was flash chromatographed over silica gel (10 mL for 0.02 mmole, gradient elution using 2-10% MeOH/CH2Cl2) to give the desired material as an oil in 75% yield, homogeneous by TLC in 10% MeOH/CH2Cl2, mass spectrum (FAB) m/e 498 (M+1)+, mp 170° C. dec.

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