Sodium Hydroxide → HCID 70284941, Verbindung

HRID 362263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 362263
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)([OH:10])[C:8](=[CH2:9])[C:4]=2[CH:3]=1.[OH-].[Na+]>ClCCl>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][CH2:9][CH:8]([C:7](=[O:10])[CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 70284478HCID 70284478, Verbindung

Produkt 1

HCID 70284941HCID 70284941, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 5-chloro-3-methylene-2-phenoxymethyl-2,3-dihydrobenzo[b]-thiophen-2-ol (16.9 g) in dichloromethane (250 ml) was shaken vigorously for a few seconds with 5M aqueous sodium hydroxide solution (150 ml), then the organic solution was separated, washed with water (150 ml), dried (MgSO4), and the solvent removed in vacuo to leave 1-(5-chloro-2,3-dihydrobenzo[b]thiophen-3-yl)-2-phenoxyethanone as a pink solid (16.4 g) which was used without further purification.

Aufarbeitung

  1. customthe organic solution was separated
  2. washwashed with water (150 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9e35c27a97f1484c816c2e9d40480353
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05869492

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