1-(5-Chloro-1-benzothiophen-3-yl)ethan-1-one → HCID 57175247, Verbindung

HRID 362265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 362265
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[C:34]([C:37]1[C:38]2[CH:45]=[C:44]([Cl:46])[CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)(=[O:36])[CH3:35]>O1CCCC1>[Br:1][CH2:35][C:34]([C:37]1[C:38]2[CH:45]=[C:44]([Cl:46])[CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)=[O:36]

Komponenten

4

Edukt 2

HCID 113901951-(5-Chloro-1-benzothiophen-3-yl)ethan-1-oneHCID 17977687Phenyltrimethylammonium bromide dibromide

Produkt 1

HCID 57175247HCID 57175247, VerbindungAusbeute 261,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Phenyltrimethylammonium tribromide (3.6 g) was added in portions under nitrogen over 30 minutes to a stirred suspension of 3-acetyl-5-chlorobenzo[b]thiophen (2 g) in tetrahydrofuran (25 ml), then the mixture was stirred at ambient temperature for 3 hours and filtered. The filter cake was washed with tetrahydrofuran (10 ml), then the filtrate and washings were combined, and the solvent removed in vacuo to leave 3-(2-bromoacetyl)-5-chlorobenzo[b]thiophen as a grey solid (4.2 g) which was used without purification.

Aufarbeitung

  1. filtrationfiltered
  2. washThe filter cake was washed with tetrahydrofuran (10 ml)
  3. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-34adb35a169843bd94fdeadebf6e35c5
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05869492

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