Methyl chloroformate → Benzoic acid, 4-(1-methylethenyl)-, methyl ester

HRID 362475

Reaktionsgleichung

Reaktionsgleichung von HRID 362475
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([CH3:8])=[CH2:7])=[CH:4][CH:3]=1.[Mg].Cl[C:13]([O:15][CH3:16])=[O:14]>C1COCC1>[C:6]([C:5]1[CH:9]=[CH:10][C:2]([C:13]([O:15][CH3:16])=[O:14])=[CH:3][CH:4]=1)([CH3:8])=[CH2:7]

Komponenten

5

Edukt 3

HCID 6586Methyl chloroformateHCID 743814-Chloro-alpha-methylstyreneHCID 5462224Magnesium

Produkt 1

HCID 11275336Benzoic acid, 4-(1-methylethenyl)-, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Preparation of the Grignard compound of 4-chloro-α-methylstyrene by means of Rieke magnesium in THF under reflux and subsequent reaction with 0.95 equivalents of methyl chloroformate at RT. Aqueous working up, extraction with ethyl acetate and column chromatography using cyclohexane/ethyl acetate 85:15 affords methyl 4-isopropenylbenzoate as colorless crystals.

Aufarbeitung

  1. temperatureunder reflux
  2. extractionextraction with ethyl acetate and column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-b9804facfb484b00bae18c748b7636e4
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05869531

Verknüpfte Notizen

Wird geladen…